This study aimed to compare the effectiveness of using brief cognitive restructuring and cognitive defusion techniques in coping with negative thoughts of college students of Laguna State Polytechnic University. The study used quasi experimental design and assigned thirty respondents in the group which was treated with cognitive restructuring and another thirty respondents in the group that was treated with cognitive defusion. t-test was used to test for the significant difference. Based from the findings of the study, there is significant difference between the mean scores of the pre-test and post-test of the restructuring group. Also, there is significant difference between the mean scores of the pre-test and post-test of the defusion group. Furthermore, mean score of the defusion group is significantly different with the mean score of restructuring group in terms of the post-test but in terms of pre-test, the mean scores of the two groups do not differ significantly.